Cost-effectiveness of Pharmaceutical-based Pandemic Influenza Mitigation Strategies1

Cost-effectiveness of Pharmaceutical-based Pandemic Influenza Mitigation Strategies1

We used a hybrid transmission and economic model to evaluate the relative merits of stockpiling antiviral drugs and vaccine for pandemic influenza mitigation. In the absence of any intervention, our base-case assumptions generated a population clinical attack rate of 31.1%. For at least some parameter values, population prepandemic vaccination strategies were effective at containing an outbreak...

Cost-effectiveness of Pharmaceutical- based Pandemic Influenza Mitigation Strategies

The states are vector structures containing 12 elements representing 3 possible vaccination groups (no-vaccine (i=1), pre-vaccine and matched vaccine (i=2) or matched vaccine only (i=3)) and 3 population groups (0-19 years (j=1), 20-64 years (j=2), and 65+ (j=3)). Susceptible states, for example, can be written as Si, i,j=1..3. The parameters ω and γ were fixed constants representing the rate o...

The Cost Effectiveness of Pandemic Influenza Interventions: A Pandemic Severity Based Analysis

BACKGROUND The impact of a newly emerged influenza pandemic will depend on its transmissibility and severity. Understanding how these pandemic features impact on the effectiveness and cost effectiveness of alternative intervention strategies is important for pandemic planning. METHODS A cost effectiveness analysis of a comprehensive range of social distancing and antiviral drug strategies int...

Cost-effectiveness analysis of pandemic influenza preparedness: what's missing?

Title: A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness